{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"da0fa32b17b348d57f5e61c41e0cfbf6ad9bb638a2b31f7e79d3758f3501ad6d","created":"2026-10-03T07:18:06Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["5475cf5dc5b1a72283d26dc95dc6e00d7ea4e00096a7c6492e409a1816eeb011"],"salt":"41b1e20b1d7fad06a10da148427ca812b70000f97c178756a839bcd0a4ec8047","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"value","assisted_by":[],"external_id":"med.microdosimetry.clustered-damage","kind":"well-posed","literature_status":"open","n":"1","parents":[],"plain":"Radiation sometimes breaks both strands of DNA at nearby places, which cells repair badly. Predicting how often this happens, starting from physics alone, is not yet possible.","posed_since":"1995","precise":"Predict the yield and complexity spectrum of DNA double-strand breaks and clustered lesions per 100 rad per cell, including the indirect chemical channel, from physical track structure plus radiation chemistry and a chromatin geometry model, without fitting to the damage data being predicted. Target accuracy: 20 percent across radiation qualities from Co-60 photons to 100 keV/micron ions. An answer is a predicted yield spectrum with that accuracy.","problem_ref":null,"references":"","settled_by":"Blind comparison of predictions with measured break yields and fragment-size distributions obtained by pulsed-field gel electrophoresis or equivalent.","status_note":"Simulation chains reproduce yields only after chromatin-model and chemistry-parameter tuning.","title":"Ab initio prediction of complex DNA damage yields","topic_ref":"72f2e40584d11439e863e00d2c447e82cf67118c73a199c7fc6c190acf8de8c7"},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"0e5bcbcb2dfce94ba005d3f63c70abd5014b6eca4f9be15965dae396cdef1008","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"b8b52813ecea040e3720034d03ad0c969a930089fbf16665b865a864d9a6e394","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"rIc3BYk6t89U4aGuB5wYJhtXJOhlyIFbk7glq_r55MBNP-aCkKTau-MhD96IzYt1C5nX14V26Nz_XqZxfd_WAg"},"schema":"pubphys.envelope/1"},"record_hash":"0e5bcbcb2dfce94ba005d3f63c70abd5014b6eca4f9be15965dae396cdef1008","leaf_index":1701}