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Predicting how often this happens, starting from physics alone, is not yet possible.","posed_since":"1995","precise":"Predict the yield and complexity spectrum of DNA double-strand breaks and clustered lesions per 100 rad per cell, including the indirect chemical channel, from physical track structure plus radiation chemistry and a chromatin geometry model, without fitting to the damage data being predicted. Target accuracy: 20 percent across radiation qualities from Co-60 photons to 100 keV/micron ions. 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