{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"c5b66a681642a25d453e7c4325d9a8db5beec8b540308093bb757a7500f38066","created":"2026-10-03T07:18:06Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["43fab9be74c232cf26b1bfc9f4763758b54afe74414bdf1a80b038b4b4c34be3","5475cf5dc5b1a72283d26dc95dc6e00d7ea4e00096a7c6492e409a1816eeb011"],"salt":"a897495c1e55b23a22e69d2b85d96e00c82e354a00a9affaa68abdf617d49b6f","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"yes-no","assisted_by":[],"external_id":"med.low-dose-risk.ct-cohorts","kind":"well-posed","literature_status":"contested","n":"1","parents":[{"note":"","parent_revision":"43fab9be74c232cf26b1bfc9f4763758b54afe74414bdf1a80b038b4b4c34be3","relation":"special_case"}],"plain":"Children scanned by CT show slightly more cancers later, but sicker children get scanned more often, which could explain the association by itself.","posed_since":"2012","precise":"Establish whether the excess leukaemia, haematological-cancer and brain-tumour incidence observed in paediatric CT cohorts, reported as excess relative risk of about 1 to 2.5 per 10 rad organ dose, is causal after removing reverse causation from scans prompted by the undiagnosed disease and from cancer-predisposition syndromes, and after correcting organ-dose reconstruction errors. An answer is a causal risk coefficient or a demonstration that the association is confounded.","problem_ref":null,"references":"","settled_by":"Cohorts with clinical indication for each scan recorded, adequate lag exclusion and individual organ-dose reconstruction.","status_note":"EPI-CT (2023; ERR about 1.3 per 10 rad for brain cancer, about 2.0 per 10 rad for haematological malignancy) and a North American cohort of about 3.7 million children (Smith-Bindman et al., NEJM 2025; ERR about 2.5 per 10 rad for haematologic cancer) report dose-related excesses; residual confounding by indication and by cancer-predisposition syndromes is still debated.","title":"Causal cancer risk from diagnostic CT exposure","topic_ref":"1948d946218d7c02b2c70b6b7a06d3d6deaab795dfb6694d5f7d48ccc81b63b1"},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"0f32be2148235efdb7ffafa46c96e431438862610f8af22b9a5c72f04299ebc2","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"6b91143537cf38bdbe44d7a25bf96862faf94ed992c4e61998f32a1ab1e683df","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"mgFbP0NRZh-0J_lAteNAYN6UdH9RTarId66518tni15j31CsPnfj8N_nH-AWq8ppGogdJTuEtOdqy5CGYe2NDQ"},"schema":"pubphys.envelope/1"},"record_hash":"0f32be2148235efdb7ffafa46c96e431438862610f8af22b9a5c72f04299ebc2","leaf_index":1699}