{"schema":"pubphys.bundle/1","record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"0a678f55a7986f2eac23ac103b0ddbaf82f30c4380d2c7fbabd9d01052194540","created":"2026-10-03T07:17:57Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["5475cf5dc5b1a72283d26dc95dc6e00d7ea4e00096a7c6492e409a1816eeb011","c9f8615966d6babc3a91fe7b5dabb8ff900ccc227835467260320f6f068052fc"],"salt":"e9a62cdc61f19b6d97f2786640ab4af7c53c5e44781810c2389f43ff8ab196c5","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"value","assisted_by":[],"external_id":"bio.origin-of-life.chirality-transfer","kind":"well-posed","literature_status":"partially-resolved","n":"1","parents":[{"note":"","parent_revision":"c9f8615966d6babc3a91fe7b5dabb8ff900ccc227835467260320f6f068052fc","relation":"special_case"}],"plain":"Life pairs right-handed sugars with left-handed amino acids, and RNA made of right-handed sugars is known to prefer attaching left-handed amino acids. Whether this preference was strong enough under early-Earth conditions to pass one chiral bias on to the other molecule family is open.","posed_since":"","precise":"D-RNA is known to favor L-amino acids in aminoacylation, and mirror-image RNA reverses the preference (Tamura and Schimmel, 2004). Find a prebiotically plausible network in which enantioenriched sugars or RNA produce free or peptide-bound L-amino acids with ee transfer factor $\\mathrm{ee}_{\\mathrm{out}}/\\mathrm{ee}_{\\mathrm{in}} \\ge 1$, under early-Earth conditions without modern enzymes, and measure it.","problem_ref":null,"references":"","settled_by":"An experiment showing that enantioenriched sugar or RNA precursors produce amino acids of the biological handedness with a measured ee transfer factor, under prebiotic conditions.","status_note":"Chiral-selective RNA aminoacylation was shown in 2004 (Science, doi 10.1126/science.1099141); amplifying transfer under prebiotic conditions has not been demonstrated, to this survey's knowledge.","title":"Prebiotic transfer of chiral bias from sugars to amino 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