{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"b1d3bfb63e5144aa43fa515ba818daa6416a52dc2a9a29d99e20fc4ab3e15826","created":"2026-10-03T07:17:57Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["5475cf5dc5b1a72283d26dc95dc6e00d7ea4e00096a7c6492e409a1816eeb011"],"salt":"621d3c263b5e0fbcb67dee20f269e2ae94de56412eaba18fde0e53b5d95ad73d","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"classification","assisted_by":[],"external_id":"bio.morphogenesis-mechanics.turing-in-vivo","kind":"well-posed","literature_status":"partially-resolved","n":"1","parents":[],"plain":"In 1952 Turing showed that two diffusing chemicals, one activating and one inhibiting, can make spots and stripes from a uniform start. Whether real fingers, hair follicles and feather buds form this way, or by cells pulling on each other, is settled for few systems.","posed_since":"1952","precise":"For a periodic pattern (vertebrate digits, hair follicles, feather buds, fish skin stripes), determine whether reaction-diffusion of the identified molecules, with measured diffusion constants and reaction rates, satisfies the Turing instability conditions and predicts the wavelength and its change with tissue size, or whether a mechanochemical instability driven by cell traction sets the pattern. Answer: a classification per system with the measured parameters.","problem_ref":null,"references":"","settled_by":"In vivo measurement of diffusion and reaction rates of the candidate molecules plus perturbations of diffusion or traction that shift the wavelength as one model predicts.","status_note":"A Bmp-Sox9-Wnt Turing network was proposed for digit patterning (Raspopovic and co-workers, Science 2014, doi 10.1126/science.1252960), while mechanical patterning was reported for feather follicles (Shyer and co-workers, 2017).","title":"Are periodic tissue patterns produced by Turing reaction-diffusion?","topic_ref":"1fc7baadfebb3e5990870988b8f4fd4fb7386c52c2949629c54fdaf55d58ea7f"},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"1f0c29fd4f75c42e803750c96088d2c7209b92c010e93ce978f9e16a31f86a09","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"301d930754d052bf43ba05d578b318d0f5d43b7c034b90cef892d40df648f678","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"WRcOT4OXTCOZAcTNhzJRDdMpp_-WErkuygbuu26NxtwUlgNRu8c7w6Sao9YhsYkuxDblFqNeIGh1QuRfQffJCw"},"schema":"pubphys.envelope/1"},"record_hash":"1f0c29fd4f75c42e803750c96088d2c7209b92c010e93ce978f9e16a31f86a09","leaf_index":802}