{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.topic/1","content_sha256":"cd513c56e5c81821203be12ec6cd8b21769953bb7cd014873092bcccb8829647","created":"2026-10-03T07:17:50Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":[],"salt":"bfe194d7548e6bfca20a6df75fd136d8a62ed21b0a97ed65213f2c621e0fcaa3","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"topic"},"content":{"external_id":"bio.biological-clocks","field":"bio","n":"1","review_cite":"Andrew C. Oates, Luis G. Morelli, Saul Ares, Patterning embryos with oscillations: structure, function and dynamics of the vertebrate segmentation clock, Development, 2012","review_link":"https://doi.org/10.1242/dev.063735","review_verified":"true","summary":"Embryos build their backbone segment by segment, timed by a genetic clock in each cell that ticks about half as fast in human cells as in mouse cells, daily clocks keep a 24-hour period whether warm or cold, and bacteria time their division so that cells stay the same size. How cells set and hold these rhythms against molecular noise and temperature changes is open.","title":"Biological clocks and timing of development and division","topic_ref":null,"why":"Timing errors in these clocks cause spine malformations and failures of cell-size control, and they test whether noisy chemistry can keep accurate time."},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"20496ed70ccc36c864251d0132a10176bf3801ad8197e51e3739d462e1620f27","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"19f57a69e72d37f2131a5806f55b8f3e77a9af7d3eb4a85b2ee1bc8b8cf547ee","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"j-z06jrno0DR3h3Hu59AkVvRBFFtBj4vs9qWcUFWfvMTl7IL-H5cxW7kmDFSTNQVHVnwD7PhQ6BGwokOvlQLAQ"},"schema":"pubphys.envelope/1"},"record_hash":"20496ed70ccc36c864251d0132a10176bf3801ad8197e51e3739d462e1620f27","leaf_index":82}