{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"4d1bfbec0d85575360196d323b4d347ee442039ba7e92f7b9674550de2fd3233","created":"2026-10-03T07:18:07Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["5475cf5dc5b1a72283d26dc95dc6e00d7ea4e00096a7c6492e409a1816eeb011"],"salt":"9c5ad719a0730715a9bee5e7b2ed8c075b7c9fa0d9b92ab07f23879df1c21be5","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"mechanism","assisted_by":[],"external_id":"med.spatial-fractionation.equivalent-dose-model","kind":"well-posed","literature_status":"open","n":"1","parents":[],"plain":"Standard formulas for converting dose into expected biological effect assume the dose is spread evenly. They fail for comb-shaped fields, and no replacement is agreed.","posed_since":"2010","precise":"Construct a model converting a spatially modulated dose distribution with peak-to-valley ratios of 10 to 100 into an equivalent uniform dose for tumour control and for normal-tissue complication, valid for single fractions of $10^{3}$ to $10^{4}$ rad peak. The linear-quadratic formalism with $\\alpha$ and $\\beta$ applied voxel by voxel is the current default and is known to fail. An answer is a model validated against measured outcomes across several geometries.","problem_ref":null,"references":"","settled_by":"Prospective prediction of tumour and normal-tissue response for geometries not used in fitting.","status_note":"","title":"Dose model for highly non-uniform fields","topic_ref":"309568a913eeab83fa370b104ac678cba3936514b3451a97889575e821f58ffd"},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"23ecc94dda44f29250ff9dc351c328f09477b3ceca45f924d54113ba267d74cb","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"bdaf73f5991eef2d50f5009c2749922b257b29678bbeace585d03abba92fd60d","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"b2-Neq-4KQ4kMVJYusKorpZ7-tZIKto4nxQukZ1u_iFG5PeplfvEwPgUhvv8GaA5uA0S9QtaeD1L3B3YWwLSDQ"},"schema":"pubphys.envelope/1"},"record_hash":"23ecc94dda44f29250ff9dc351c328f09477b3ceca45f924d54113ba267d74cb","leaf_index":1727}