{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"fe1d535058ff95261e0ef23b834a50f1707de08757d443e268201528f69b497f","created":"2026-10-03T07:18:07Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["5475cf5dc5b1a72283d26dc95dc6e00d7ea4e00096a7c6492e409a1816eeb011"],"salt":"89cd239c692ec8cb07f9368f45e51fbf43dcebd8db9a96137a0fed7bce30493b","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"value","assisted_by":[],"external_id":"med.radionuclide-therapy.small-scale","kind":"well-posed","literature_status":"open","n":"1","parents":[],"plain":"Organ-average dose hides the fact that a drug concentrates in particular microscopic structures, such as parts of the kidney filter or pockets of bone marrow.","posed_since":"1995","precise":"Compute absorbed dose at the scale of 10 to 1000 micron in kidney (glomerulus, proximal tubule, interstitium) and in red marrow cavities, including non-uniform uptake and beta particle ranges in tissue of about 0.7 mm mean (2 mm maximum) for Lu-177 and about 2.5 mm mean (11 mm maximum) for Y-90, and relate it to the organ-average dose currently used. An answer is a set of small-scale to organ-average dose ratios with their uncertainty.","problem_ref":null,"references":"","settled_by":"Autoradiography or high-resolution imaging of activity distribution in tissue combined with transport calculation, compared against toxicity.","status_note":"","title":"Dose at the scale of nephrons and marrow cavities","topic_ref":"6c8bec8f6507d1401333ef1f0d3b8af96544abd2d55b8980500938f7c5f01fb2"},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"2f5a194688cd84e3da210d42cbcc78897d5639b57e6c70033dfb816fb15dbb27","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"6a99e4535ebf4cf79df5956ce19886dba7252b22f43ed330d4f1ba2a3133d2b2","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"rsqs7xf95NGRyzljO3RFyr2rOx5W6gBxF4m5V1Iovgpowepdqprm6YLXWEga3ANABFSnjcBha5DRw6nuo3DYAA"},"schema":"pubphys.envelope/1"},"record_hash":"2f5a194688cd84e3da210d42cbcc78897d5639b57e6c70033dfb816fb15dbb27","leaf_index":1724}