{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"718468c1ffaf5ac4511e47e64f9b6c4f3590886628c5e23b93f6a7c8cd7d8bcb","created":"2026-10-03T07:18:06Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["5475cf5dc5b1a72283d26dc95dc6e00d7ea4e00096a7c6492e409a1816eeb011"],"salt":"fd6b3e141dfea4788522a6034ca2434d62a4d0b1b9a4baee0332b37c0b6250ea","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"yes-no","assisted_by":[],"external_id":"med.flash.human-sparing","kind":"well-posed","literature_status":"open","n":"1","parents":[],"plain":"The tissue-protecting effect of ultra-fast radiation has been shown mostly in mice and other animals. Whether it happens in people at clinically useful doses has not been measured.","posed_since":"2019","precise":"Determine whether single-fraction doses of 800 to 3000 rad delivered at mean dose rates above 4000 rad/s produce measurably lower normal-tissue toxicity in humans than the same dose at conventional dose rates of 1 to 10 rad/s, at matched tumour control, for at least one tissue and endpoint. An answer is yes or no with an estimated dose-modifying factor and confidence interval.","problem_ref":null,"references":"","settled_by":"A randomized clinical comparison of FLASH and conventional dose rate at equal dose with a prespecified normal-tissue endpoint.","status_note":"The FAST-01 trial (Mascia et al., JAMA Oncology 2023) showed feasibility of proton FLASH at 800 rad in 10 patients with bone metastases, with no conventional-dose-rate comparison arm; no randomized toxicity comparison was found in the sources checked.","title":"Does the FLASH sparing effect occur in human normal tissue","topic_ref":"e183d5a2701f7e11dac3a5238c81e6d9a173fcc98c4f033d2937f114642a72e0"},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"61a45b6778062f41d6ad2f72489390ac1c464456ee2c80329da43c641e179d8b","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"a60c542037b7827bf5c82bdc2201e5daee836ddba163ddf9874e2b01ce47b16c","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"niIlk9MXyA6Cdk07qWEAQ0GN_hDSD1RWTaHVwSUC1z8zU9ojqHFnL4q0afiCb2LwJzK8PFen3yPRTg7Rc5kkDw"},"schema":"pubphys.envelope/1"},"record_hash":"61a45b6778062f41d6ad2f72489390ac1c464456ee2c80329da43c641e179d8b","leaf_index":1681}