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Where to place the bin edges for the best material separation at the lowest dose is unsolved in general.","posed_since":"2010","precise":"Determine the energy threshold set that minimizes the variance of material-decomposition estimates for a given task, tube spectrum, patient thickness and dose, including the detector response with charge sharing and pileup. Compare against the Cramer-Rao bound (the minimum variance any unbiased estimator can reach) achievable with full spectral information. 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