{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"deb6aaeb0ce5015dcce9c0f4d341942083f1a141eda6e9031586fc8ef2cca3d7","created":"2026-10-03T07:18:06Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["5475cf5dc5b1a72283d26dc95dc6e00d7ea4e00096a7c6492e409a1816eeb011"],"salt":"1c21ce9875fa1c4789eb475955443b418f928f80cdc081f4a56ad0a9a8946832","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"identification","assisted_by":[],"external_id":"med.low-dose-risk.individual-sensitivity","kind":"well-posed","literature_status":"open","n":"1","parents":[],"plain":"A minority of patients suffer unusually severe side effects from standard radiotherapy doses. There is no reliable test to find them in advance.","posed_since":"1990","precise":"Identify an assay predicting severe normal-tissue reaction, defined as grade 3 or higher toxicity, before treatment, with sensitivity and specificity sufficient for clinical use. Candidate physical and cellular measures: residual DNA double-strand break foci at 24 h, chromosome aberration yield per 100 rad in lymphocytes, and apoptosis fraction after ex vivo irradiation. An answer names a validated assay with its operating characteristics.","problem_ref":null,"references":"","settled_by":"Prospective blinded validation of a candidate assay against observed toxicity in a treated cohort.","status_note":"A lymphocyte apoptosis assay was validated prospectively for late breast fibrosis in 2015 (Azria et al., EBioMedicine), with discrimination too modest for routine clinical use.","title":"Physical markers of individual radiosensitivity","topic_ref":"1948d946218d7c02b2c70b6b7a06d3d6deaab795dfb6694d5f7d48ccc81b63b1"},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"838b9bda30ff3474fb79acf38a8392e0f90096d4d2ffd6e0e58b24adb2ce9b94","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"bbf196c0a307c9d71b4a2d2ca1d338ad71673050ffba49dd4f0dc12b66e7346d","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"8eCqH1LogWan0TI6QBrXGI4SuSvPneI235ljU_IMIKkK7h1im8iCaq_YRGTJjlpG-rc1FMh1kiX0FKIfiO63Aw"},"schema":"pubphys.envelope/1"},"record_hash":"838b9bda30ff3474fb79acf38a8392e0f90096d4d2ffd6e0e58b24adb2ce9b94","leaf_index":1697}