{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.topic/1","content_sha256":"74427cd2feb2fcfefe7c7a182a9ea7d0e9815abcee8de7bdd71c534169b334f9","created":"2026-10-03T07:17:50Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":[],"salt":"97e551d3639b70f78c12e3d3a6f2cd9f1152205cea37445713b79be8a21b6f43","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"topic"},"content":{"external_id":"bio.chromatin-extrusion","field":"bio","n":"1","review_cite":"Iain F. Davidson, Jan-Michael Peters, Genome folding through loop extrusion by SMC complexes, Nature Reviews Molecular Cell Biology, 2021","review_link":"https://doi.org/10.1038/s41580-021-00349-7","review_verified":"true","summary":"Each human cell packs about 200 cm of DNA into a nucleus about 0.001 cm across, yet keeps genes accessible. Protein motors called cohesin and condensin pull DNA into loops, and how this and other forces organize the genome is still being worked out.","title":"Chromatin organization and loop extrusion","topic_ref":null,"why":"Genome folding controls which genes are switched on and how chromosomes separate at cell division."},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"8ad1a941274484056fe235f47000030ee6a6486f2d2e01d87c8ec53a250ea12e","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"039dad23fd724366be29a2f2aac55a1e0e77273f7554e2ba1fcc9f25da514c81","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"C9KlBztoB-cKUaRDGtXMQo07FEf5NhStIpYsSkgsqU_mKDYYyPBCMxeZ4f-JtAo1E4CXZokD_UowFa0QCFPqAg"},"schema":"pubphys.envelope/1"},"record_hash":"8ad1a941274484056fe235f47000030ee6a6486f2d2e01d87c8ec53a250ea12e","leaf_index":84}