{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"6fa4d79aff20a179b0df05c651a2b1798dab7b24dd1082293aaca4e16726691e","created":"2026-10-15T23:43:22Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["ce59fb6cd812fc05906d0c60a71c75ea22bc686bcf38e7c3ef7010834d98ee7b","eb4ebc3d8217d58dcc9db855e02324a902e876a74d5822fb4e70338b3f914b15"],"salt":"7c3ebfdb52f4b3d1d720ea32e0b5d854a36f6c35e6e4bf4002b8e2f8b470bca5","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"yes-no","assisted_by":[],"external_id":"med.radionuclide-therapy.dose-response","kind":"well-posed","literature_status":"partially-resolved","n":"2","parents":[],"plain":"In external beam treatment, more dose means more tumour control. Whether the same holds for radioactive drugs, where dose arrives slowly and unevenly, has not been shown convincingly.","posed_since":"2000","precise":"Establish whether tumour absorbed dose, computed from quantitative imaging and time-activity integration for Lu-177 labelled agents, predicts response with a slope distinguishable from zero, and whether kidney and marrow absorbed dose predicts toxicity. Typical delivered tumour doses span $10^3$ to $3 \\times 10^4\\,\\mathrm{rad}$ at dose rates of 1 to 100 rad/h. An answer is a dose-response relation with confidence intervals, or a demonstration that dose rate and biological factors dominate.","problem_ref":"eb4ebc3d8217d58dcc9db855e02324a902e876a74d5822fb4e70338b3f914b15","references":"","settled_by":"Prospective trials randomizing or stratifying by measured absorbed dose rather than administered activity.","status_note":"Dosimetry-guided dose escalation studies reported through 2024 support a relation for some agents; fixed-activity dosing remains standard practice.","title":"Does absorbed dose predict outcome in radionuclide therapy?","topic_ref":null},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"9eb0e68813dc502823f504fe5660e2a189ac20c1398a776cb91db1d2bd5c4fe6","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"b38413838290b4b91f0ced92f301654a0b79db8c7f1ffa699860db99c280db77","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"Yf0AwTj-ARzqHM7yh0tBslfDuqc3s-7GaaMTMvERxLGJRiz7f8SacP6ijvqE_V-gDqnlR1l3ZSMyMmiuB_HxBg"},"schema":"pubphys.envelope/1"},"record_hash":"9eb0e68813dc502823f504fe5660e2a189ac20c1398a776cb91db1d2bd5c4fe6","leaf_index":3484}