{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"817492144885f64c6a3883e68be77e36f66c03fe501fa9f4225301dabdaacd16","created":"2026-10-03T07:18:07Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["5475cf5dc5b1a72283d26dc95dc6e00d7ea4e00096a7c6492e409a1816eeb011"],"salt":"2ccd82388c518531911dcc9e1cea9f1a4f9916784ab58fe8dad627bf3e5a0cff","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"value","assisted_by":[],"external_id":"med.radionuclide-therapy.alpha-microdosimetry","kind":"well-posed","literature_status":"open","n":"1","parents":[],"plain":"Alpha-emitting drugs release a chain of short-lived radioactive descendants, which can break free of the carrier molecule and travel elsewhere in the body before decaying. Where that dose ends up is not known.","posed_since":"2010","precise":"Determine the absorbed dose at cellular scale from Ac-225 and Ra-223 chains, including recoil-induced release of daughters (Fr-221, Bi-213, Pb-209 for Ac-225) and their redistribution, given alpha ranges of 40 to 100 micron and hit numbers of order a few per cell nucleus. An answer is a microdosimetric specific-energy distribution per organ and tumour, with measured daughter redistribution fractions.","problem_ref":null,"references":"","settled_by":"Direct measurement of daughter biodistribution combined with stochastic microdosimetric calculation validated by cellular damage endpoints.","status_note":"Daughter redistribution, particularly to kidney and bone marrow, was recognized but not quantified in patients as of 2025.","title":"Microdosimetry of $\\alpha$ emitters with mobile daughters","topic_ref":"6c8bec8f6507d1401333ef1f0d3b8af96544abd2d55b8980500938f7c5f01fb2"},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"ba8f8480d508df0cdbd3c626f7b15ee4dbbb45ca4897db6a69694e5c913b573e","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"3dfa9abe97239f88acb2d84cfee547b1221cf51693dd4b395d40ebc438826e72","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"Qp_2ikjuL7RawBxKfHId-qJEHjGNmc8diSppx-k-9FV9gzgplGmQhvwHrgoxrTfhv9Zs1cfk4806VQoDKpkvCg"},"schema":"pubphys.envelope/1"},"record_hash":"ba8f8480d508df0cdbd3c626f7b15ee4dbbb45ca4897db6a69694e5c913b573e","leaf_index":1719}