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Experiments give mixed support, and which statistical class real mutations follow is unsettled.","posed_since":"","precise":"If the wild type is near the top of the fitness distribution of its mutational neighbors, extreme-value theory predicts exponentially distributed beneficial selection coefficients s (Gumbel domain), with Weibull (bounded) or Frechet (heavy-tailed) alternatives. Determine the domain of attraction from large mutant libraries (deep mutational scanning, barcoded lineage tracking) across organisms and environments, and how it depends on distance from the optimum.","problem_ref":null,"references":"","settled_by":"Large-library measurements of beneficial effects with tail-shape estimation across several organisms and environments.","status_note":"","title":"Distribution of fitness effects of beneficial 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