{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"7a85fd3dea9ab3c88030014cc6e3b6bbea515caf55a60dee91ddf72342b33479","created":"2026-10-03T07:18:06Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["5475cf5dc5b1a72283d26dc95dc6e00d7ea4e00096a7c6492e409a1816eeb011"],"salt":"c5c85d41535abfa6c47939ecf936686a6d9ca7e77b69942e14aba5046ba149be","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"value","assisted_by":[],"external_id":"med.bnct.in-vivo-boron-imaging","kind":"well-posed","literature_status":"open","n":"1","parents":[],"plain":"Each boron capture emits a gamma ray of a specific energy, which could in principle be used to map the boron during treatment. A working scanner that does this accurately in a patient does not exist.","posed_since":"","precise":"Image the B-10 concentration in tissue during neutron irradiation through the 478 keV gamma line from the Li-7 excited state, with 10 percent accuracy in concentration, about 5 mm spatial resolution and a frame time of minutes, against the intense background of 2.2 MeV hydrogen-capture gammas and neutron-induced detector activation. An answer is a demonstrated detector and reconstruction method with these figures in a patient-sized phantom.","problem_ref":null,"references":"","settled_by":"Phantom measurements with known boron distributions in a clinical epithermal beam showing the stated concentration accuracy and resolution.","status_note":"Prompt-gamma tomography prototypes for neutron capture therapy were in development without clinical use.","title":"Real-time imaging of boron concentration during irradiation","topic_ref":"0c8039c980b31f825989ca36e1cd7529f5aab83d616e66638b0e9746fc03ac15"},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"cf94d8ac0e6bb74748b67c032e939f9471057bb16a0036e15147156673ac290a","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"f0312f41bf2701ab33f69e9c798b2f63f2ea7b93c7993abaaadea0377dd7f672","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"QMZDpzJWwuJJROZO7mXtr55L8iDUoo1dFLSnlAMOwsfdh2HX4CZ_yPFyaICZI5FWeuYnzKNbKGMgNN5xOhkaCA"},"schema":"pubphys.envelope/1"},"record_hash":"cf94d8ac0e6bb74748b67c032e939f9471057bb16a0036e15147156673ac290a","leaf_index":1667}