{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"767f163a9b5b2f14591d2be46990835f8974df0237c3830b4623c6a2cd93a463","created":"2026-10-03T07:17:57Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["5475cf5dc5b1a72283d26dc95dc6e00d7ea4e00096a7c6492e409a1816eeb011"],"salt":"836c619342c51f4284beeb9d169f48b27c7c6c463b7e5e222ef7a14f1659a582","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"mechanism","assisted_by":[],"external_id":"bio.biological-clocks.temperature-compensation","kind":"phenomenon","literature_status":"open","n":"1","parents":[],"plain":"Most chemical reactions speed up strongly when warmed, yet circadian clocks, the cell's 24-hour timers, keep nearly the same period over a wide range of temperatures. How the clock cancels the temperature dependence of its reactions is not understood.","posed_since":"1954","precise":"For the KaiABC oscillator in vitro, the period has $Q_{10}$ of approximately 1.1 between about 298 and 308 K while individual rate constants have $Q_{10} \\sim 2$ to 3 ($Q_{10}$ = rate ratio for a 10 K rise). Identify the mechanism (balanced activation energies of opposing reactions, temperature-insensitive KaiC ATPase, structural constraint) that makes $d \\ln(\\mathrm{period})/dT$ small, and predict the period's temperature dependence from measured rate constants.","problem_ref":null,"references":"","settled_by":"A kinetic model built from independently measured temperature-dependent rate constants that predicts the period versus temperature and the effect of mutations that break compensation.","status_note":"","title":"Mechanism of temperature compensation in circadian clocks","topic_ref":"20496ed70ccc36c864251d0132a10176bf3801ad8197e51e3739d462e1620f27"},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"d51cdca114f53629c8f01fca791ed12d9998ca36a472cfda70d6b7275ab6f060","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"f7516b6566e95c8d86a9347a212b0bc04d5e9249c9523e0d75ba79e4d57fac25","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"Z2yuEaUX8Trxc12R2DTv3A20ErTaaSvLuigmMtIPjwQVD5h-39O3TnXhiGweBYOlQf6Arr1Em26EHFE9xcKkDA"},"schema":"pubphys.envelope/1"},"record_hash":"d51cdca114f53629c8f01fca791ed12d9998ca36a472cfda70d6b7275ab6f060","leaf_index":733}