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How the clock cancels the temperature dependence of its reactions is not understood.","posed_since":"1954","precise":"For the KaiABC oscillator in vitro, the period has $Q_{10}$ of approximately 1.1 between about 298 and 308 K while individual rate constants have $Q_{10} \\sim 2$ to 3 ($Q_{10}$ = rate ratio for a 10 K rise). Identify the mechanism (balanced activation energies of opposing reactions, temperature-insensitive KaiC ATPase, structural constraint) that makes $d \\ln(\\mathrm{period})/dT$ small, and predict the period's temperature dependence from measured rate constants.","problem_ref":null,"references":"","settled_by":"A kinetic model built from independently measured temperature-dependent rate constants that predicts the period versus temperature and the effect of mutations that break compensation.","status_note":"","title":"Mechanism of temperature compensation in circadian 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