{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"8dc03cc2c75071edba55f5c8a11bdbe5081f02e80552dc657ea87c7a885099f6","created":"2026-10-03T07:18:07Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["5475cf5dc5b1a72283d26dc95dc6e00d7ea4e00096a7c6492e409a1816eeb011"],"salt":"3b9b5246354b84e05bd5e8f2d4a3f19cb72220b646c2cb05a2646fff379878e7","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"yes-no","assisted_by":[],"external_id":"med.radionuclide-therapy.dose-response","kind":"well-posed","literature_status":"partially-resolved","n":"1","parents":[],"plain":"In external beam treatment, more dose means more tumour control. Whether the same holds for radioactive drugs, where dose arrives slowly and unevenly, has not been shown convincingly.","posed_since":"2000","precise":"Establish whether tumour absorbed dose, computed from quantitative imaging and time-activity integration for Lu-177 labelled agents, predicts response with a slope distinguishable from zero, and whether kidney and marrow absorbed dose predicts toxicity. Typical delivered tumour doses span $10^3$ to $3 x 10^4\\,\\mathrm{rad}$ at dose rates of 1 to 100 rad/h. An answer is a dose-response relation with confidence intervals, or a demonstration that dose rate and biological factors dominate.","problem_ref":null,"references":"","settled_by":"Prospective trials randomizing or stratifying by measured absorbed dose rather than administered activity.","status_note":"Dosimetry-guided dose escalation studies reported through 2024 support a relation for some agents; fixed-activity dosing remains standard practice.","title":"Does absorbed dose predict outcome in radionuclide therapy","topic_ref":"6c8bec8f6507d1401333ef1f0d3b8af96544abd2d55b8980500938f7c5f01fb2"},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"eb4ebc3d8217d58dcc9db855e02324a902e876a74d5822fb4e70338b3f914b15","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"237480a879f522d4b6eb4709f1371daba170cd5b142b3860eeb53f772e8caaff","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"_nxORDUgHrVR5Jbh6GHcGpZ0smHunOqaAJT00wDelb3MriJO2l0LWldqVrfOy2ZCJ7DiM6yFgKP-R-RNzjAGAw"},"schema":"pubphys.envelope/1"},"record_hash":"eb4ebc3d8217d58dcc9db855e02324a902e876a74d5822fb4e70338b3f914b15","leaf_index":1721}