{"schema":"pubphys.bundle/1","record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"523832858351f13e1f368758f78aeb013f0d14f2dc2f3bb2e46001640cebf1b4","created":"2026-10-03T07:17:57Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["5475cf5dc5b1a72283d26dc95dc6e00d7ea4e00096a7c6492e409a1816eeb011"],"salt":"ca7fdd8e44106eacf8b76965e986e2cb6bef7afa2d28d4e5a44971541a18b68e","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"value","assisted_by":[],"external_id":"bio.condensates.sequence-to-phase","kind":"well-posed","literature_status":"partially-resolved","n":"1","parents":[],"plain":"A disordered protein's amino-acid sequence decides at what concentration it forms droplets. A method that predicts this concentration from sequence, across salt and temperature, would connect sequence to physics directly.","posed_since":"","precise":"For intrinsically disordered regions of 50 to 500 residues, predict the saturation concentration $c_{\\mathrm{sat}}(T,\\mathrm{salt})$ and the dense-phase concentration from sequence alone, within a factor of 2 for $c_{\\mathrm{sat}}$, across sequence variants with altered aromatic and charge patterning (stickers-and-spacers framework). Answer: a model validated on blind variants and on two-component mixtures.","problem_ref":null,"references":"","settled_by":"Blind predictions of $c_{\\mathrm{sat}}$ for newly designed sequence variants compared with measured phase diagrams.","status_note":"Residue-level coarse-grained models reproduce $c_{\\mathrm{sat}}$ trends within families of disordered regions; accuracy for arbitrary sequences and mixtures is not established as of 2026, to this survey's knowledge.","title":"Predict condensate phase diagrams from protein 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