{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"048c504dcf165698d05857991a006ed2b801f6b35e6a8869214b9045a9153e9f","created":"2026-10-03T07:17:57Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["5475cf5dc5b1a72283d26dc95dc6e00d7ea4e00096a7c6492e409a1816eeb011"],"salt":"0a1d0f2fc6bd2f8c13efc8044c52f6ed90fe87989b44815dfd6236e3dd8f544b","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"yes-no","assisted_by":[],"external_id":"bio.morphogenesis-mechanics.flow-from-myosin","kind":"well-posed","literature_status":"partially-resolved","n":"1","parents":[],"plain":"During early development, sheets of cells flow across the embryo as motor proteins pull on them. A test of understanding is to predict these flows, and the resulting shapes, from the measured pattern of motor activity alone.","posed_since":"2018","precise":"For whole-embryo morphogenesis (e.g., Drosophila gastrulation and germ-band extension), formulate a continuum model (thin viscous shell with active stress proportional to measured myosin density) whose velocity field v(x, t) matches light-sheet tissue-flow data with correlation above 0.9 over the full process, including later stages with cell intercalation and tissue folding, using one parameter set. Answer: yes or no, with the model and its quantitative fit.","problem_ref":null,"references":"","settled_by":"A fixed-parameter model fit to whole-embryo myosin and flow data across all gastrulation stages, validated on myosin-perturbed mutants.","status_note":"A 2018 study (Streichan and co-workers) predicted early Drosophila gastrulation flow from the myosin pattern with a Stokes-flow model; later stages and folding remain open.","title":"Predict embryo-scale tissue flow from measured motor activity","topic_ref":"1fc7baadfebb3e5990870988b8f4fd4fb7386c52c2949629c54fdaf55d58ea7f"},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"fa9f944d5103146f30a4330554fc82d7baed49ff29e5fca44c9ca8e36f44a318","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"d17c4106aab98765167a3b2e53ea4fde00aea9709b368cfcfb7f29ffdcdca19f","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"fRckFWSdX_Tq99BUPajAKQj53iqCG--EkEiPYH3dS9BNZn-ivyVa5prHdUSX2mqAlqc6zBccim28UwHEnKuUAQ"},"schema":"pubphys.envelope/1"},"record_hash":"fa9f944d5103146f30a4330554fc82d7baed49ff29e5fca44c9ca8e36f44a318","leaf_index":797}