{"record":{"author":{"account_ref":null,"orcid":null},"builds_on":[],"content_schema":"pubphys.content.revision/1","content_sha256":"702a452a93f927ae7c4bbc17e0feb64eaa2803d5ebf8c5fddfad5a6e67882512","created":"2026-10-03T07:18:07Z","files":[],"origin":{"assisted_by":[],"kind":"seed"},"parents":["5475cf5dc5b1a72283d26dc95dc6e00d7ea4e00096a7c6492e409a1816eeb011"],"salt":"62eb788763f70732cd54bcc4d566c744a83c654aa862cd0162dd67e4ef04a489","schema":"pubphys.record/2","site":"pubphys.com","target":null,"type":"revision"},"content":{"answer_type":"value","assisted_by":[],"external_id":"med.radionuclide-therapy.production-routes","kind":"well-posed","literature_status":"partially-resolved","n":"1","parents":[],"plain":"The most promising alpha-emitting drugs are limited by how little of the isotope can be made. Which production reaction is best is not settled.","posed_since":"2010","precise":"Determine the optimal production route for Ac-225 and related $\\alpha$ emitters by measuring excitation functions and co-produced impurities for proton spallation of thorium-232, photonuclear production from Ra-226, and deuteron or $\\alpha$ routes, in the energy ranges used by available accelerators. Key figure of merit: yield per beam hour at required radionuclidic purity, in particular Ac-227 contamination. An answer is cross sections and yields fixing the preferred route.","problem_ref":null,"references":"","settled_by":"Measured excitation functions and target tests reporting yield and impurity levels for each route.","status_note":"Accelerator routes expanded supply after about 2018 while impurity control and scale-up remained limiting.","title":"Accelerator production routes for therapeutic alpha emitters","topic_ref":"6c8bec8f6507d1401333ef1f0d3b8af96544abd2d55b8980500938f7c5f01fb2"},"attested":{"attestation":{"batch":null,"client_id":null,"id_token_sha256":null,"kind":"platform"},"record_hash":"fc9752740fad0bccffc81019c201349407e1ed8b5425bff18c2d5615f44d9eff","schema":"pubphys.attested/1"},"envelope":{"attested_hash":"6f79bf4bef6d5b4abcd0fb77052724a92c755f2ff67b4bbb5d64830bae65fd71","platform_signature":{"key_id":"c6afc19b31429869751f06879c75cd64ea92654423d15b44be775bf1310a60da","sig":"-zcz99E0YxbjtYe0c3hkU1UXmIG9sgIDlSnWcKv3lNv9blo52JFAbUEE3JIwdV7cKJVGELZ12SFjQuJJ6fj1Ag"},"schema":"pubphys.envelope/1"},"record_hash":"fc9752740fad0bccffc81019c201349407e1ed8b5425bff18c2d5615f44d9eff","leaf_index":1722}