Revision 2

Accepted · core change · record

Changes against revision 1:

Title: Predicting and controlling histotripsy bubble clouds
Plain: Very short, very intense sound pulses tear tissue apart mechanically by creating clouds of bubbles. Where and when those clouds form is only partly predictable.
Precise · changed · core: Revision 1: Predict the threshold and spatial extent of histotripsy bubble-cloud formation from the incident pressure waveform, with peak negative pressures of $10^8\text{ to }3 x 10^8\,\mathrm{dyn}/\mathrm{cm}^2$ and microsecond pulses, including nucleus distribution in tissue, shock scattering from earlier bubbles, and tissue mechanical properties. An answer is a predictive model giving the treated volume boundary to within $1\,\mathrm{mm}$.; Revision 2: Predict the threshold and spatial extent of histotripsy bubble-cloud formation from the incident pressure waveform, with peak negative pressures of $10^8\text{ to }3 \times 10^8\,\mathrm{dyn}/\mathrm{cm}^2$ and microsecond pulses, including nucleus distribution in tissue, shock scattering from earlier bubbles, and tissue mechanical properties. An answer is a predictive model giving the treated volume boundary to within $1\,\mathrm{mm}$.
Settled by: High-speed imaging and acoustic measurement of cloud formation across pressure and tissue type, compared with the model prediction and the resulting lesion.
Kind: well-posed
Answer type: mechanism
References: (empty)
Literature status: open
Status note: (empty)
Posed since: 2004

Decisions