Revision 1

Accepted · first revision · record

Title: In vivo relevance of bystander and non-targeted effects
Plain: Cells that were never hit by radiation sometimes show damage because neighbours were hit. Whether this matters in a living body at low dose is unknown.
Precise: Determine whether bystander signalling, genomic instability and abscopal responses change organ-level risk at doses below 10 rad in vivo, relative to the prediction from directly hit cells alone. Required: dose range, signalling distance in tissue, and persistence. An answer is a quantified modification factor or a demonstration that it is negligible.
Settled by: In vivo experiments with spatially restricted irradiation, such as microbeam or partial-body exposure, measuring effects in unirradiated tissue at low dose.
Kind: well-posed
Answer type: yes-no
References: (empty)
Literature status: open
Status note: (empty)
Posed since: 1992