Revision 1

Accepted · first revision · record

Title: Accelerator production routes for therapeutic alpha emitters
Plain: The most promising alpha-emitting drugs are limited by how little of the isotope can be made. Which production reaction is best is not settled.
Precise: Determine the optimal production route for Ac-225 and related $\alpha$ emitters by measuring excitation functions and co-produced impurities for proton spallation of thorium-232, photonuclear production from Ra-226, and deuteron or $\alpha$ routes, in the energy ranges used by available accelerators. Key figure of merit: yield per beam hour at required radionuclidic purity, in particular Ac-227 contamination. An answer is cross sections and yields fixing the preferred route.
Settled by: Measured excitation functions and target tests reporting yield and impurity levels for each route.
Kind: well-posed
Answer type: value
References: (empty)
Literature status: partially-resolved
Status note: Accelerator routes expanded supply after about 2018 while impurity control and scale-up remained limiting.
Posed since: 2010